Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23, selectively expressed in secretory cells compared with ciliated and basal cells of airway epithelium by immunohistochemistry and FACS, suggesting that SNAP23 functions in regulated but not constitutive epithelial secretion. Heterozygous SNAP23 deletant mutant mice show spontaneous accumulation of intracellular mucin, indicating a defect in baseline secretion. However mucins are released from perfused tracheas of mutant and wild-type mice at the (...) same rate, suggesting that increased intracellular stores balance reduced release efficiency to yield a fully compensated baseline steady state. In contrast, acute stimulated release of intracellular mucin from mutant mice is impaired whether measured by a static imaging assay 5 min after exposure to the secretagogue ATP or by kinetic analysis of mucins released from perfused tracheas during the first 10 min of ATP exposure. Together, these data indicate that increased intracellular stores cannot fully compensate for the defect in release efficiency during intense stimulation. The lungs of mutant mice develop normally and clear bacteria and instilled polystyrene beads comparable to WT mice, consistent with these functions depending on baseline secretion that is fully compensated. (shrink)

Burton F. Porter explores the philosophical question of the existence of God in an open, yet critical, way, examining the argumentation used by centuries of human society to support or reject divinity.

Prof. Burton Porter surveys philosophy and ethics in a clear, concise way, examines our present attitudes and values, and offers signposts for a successful life. With full, 21st century awareness, the author points to dimensions of human beings that can be realized to create a fulfilling existence.

This book describes the "naturalistic fallacy", as attributed to Hume, that non-moral premises cannot logically entail a moral conclusion, and distinguishes it from the similarly named though subtly different fallacy identified by Moore in Principia Ethica by comparing and contrasting its presence in a range of ethical or moral systems. A review of Hume’s position elicits the implications to theological naturalism, and how this relates to Kierkegaard’s "paradox of faith" and the doctrine of ineffability. Methods of logical examination of religious (...) language are discussed, leading to the dissection of the analytic proposition that ‘God is Good’ and of the connotations of proper names. Porter concludes from this a solution to the naturalistic fallacy: that "good" is essential to "God" by definition, and therefore that premises relating to God must contain an inherent morality. Originally published in 1968, this book includes topics such as Mediaeval attitudes to deity and morality; Religious myth, images and language; Comparative conceptions of deity. (shrink)

This book describes the "naturalistic fallacy", as attributed to Hume, that non-moral premises cannot logically entail a moral conclusion, and distinguishes it from the similarly named though subtly different fallacy identified by Moore in Principia Ethica by comparing and contrasting its presence in a range of ethical or moral systems. A review of Hume’s position elicits the implications to theological naturalism, and how this relates to Kierkegaard’s "paradox of faith" and the doctrine of ineffability. Methods of logical examination of religious (...) language are discussed, leading to the dissection of the analytic proposition that ‘God is Good’ and of the connotations of proper names. Porter concludes from this a solution to the naturalistic fallacy: that "good" is essential to "God" by definition, and therefore that premises relating to God must contain an inherent morality. Originally published in 1968, this book includes topics such as Mediaeval attitudes to deity and morality; Religious myth, images and language; Comparative conceptions of deity. (shrink)

Intended for use in the introduction to ethics course, this text is designed to engage today's practical-minded student in more fundamental questions. The book ranges from ideals in living to contemporary moral problems, exploring and analyzing both areas in order to stimulate deeper reflection.

Introduction: The spectrum and the poles -- Seeking truth or pursuing happiness -- Just deserts or divine forgiveness -- Our conduct as forced or free -- Religious faith and rational doubt -- Individual rights and the common good -- Human I.Q. and animal feeling -- Asceticism and sensuality -- The populist and elitist perspectives -- Self-interest and self-sacrifice -- Truth as invented or discovered -- Men and women : categories or constructs -- Trusting our senses or being rational -- Northern (...) efficiency and Southern charm. (shrink)

The Fundamentals of Ethics is a textbook that introduces students to the central ideas of moral philosophy in a thorough yet compact and engaging way. It contains several chapters each on The Good Life, Normative Ethics, and Metaethics. It has greater breadth and depth than Rachels' The Elements of Moral Philosophy, offering a substantial level of analysis while also keeping the student reader in mind. Writing in a lively style with many examples, the author reconstructs and carefully evaluates over forty (...) central arguments in moral philosophy, helping students to improve their critical thinking skills along the way. It is designed to be used on its own or in conjunction with The Ethical Life, the companion reader. (shrink)

What the Tortoise Taught Us offers a lively, concise journey through western philosophy that explores the lives of major philosophers, their ideas, and how their thinking continues to influence our lives today.

What the Tortoise Taught Us offers a lively, concise journey through western philosophy that explores the lives of major philosophers, their ideas, and how their thinking continues to influence our lives today.

We extend the Theory of Planned Behavior (TPB) for ethics in the workplace. Using a path modeling methodology, we find evidence that, for ethics, moral disengagement is an antecedent to the TPB predictors of attitude, subjective norms, and perceived behavioral control (PBC). We show that the TPB predictors mediate the influence moral disengagement has on ethical behavioral intentions. Thus, to improve ethical behavior, reducing moral disengagement is critical. We find support for including both types of PBC (self-efficacy and locus of (...) control) when modeling ethical behavior. We use four ethics scenarios and international data to test this model. We also evaluate potential positive influences on ethics in the workplace and find that recency of ethics training interacts with religiosity and activates it to reduce moral disengagement. We also find that principles-based ethics training enhances professionals’ self-efficacy to behave ethically. Experience, including time as a member in a professional accounting organization, increases both locus of control and self-efficacy to behave ethically. These variables—recency of ethical training, religiosity, principles-based professional ethics training, and experience—influence parts of the core TPB model, which in turn lead to improved ethical behavioral intentions. (shrink)

Lively, comprehensive, and contemporary, The Voice of Reason: Fundamentals of Critical Thinking covers three principal areas: thought and language, systematic reasoning, and modes of proof. It employs highly accessible explanations and a multitude of examples drawn from social issues and various academic fields, showing students and other readers how to construct and criticize arguments using the techniques of sound reasoning. The Voice of Reason examines the traditional elements of the field and also explores new ground. The first section of the (...) book elucidates the relationship between thought and language, explaining how words function. It discusses meaning, connotation, vagueness, ambiguity, and definition, identifying the linguistic elements that can produce mistakes in thinking. The next section describes the rules of systematic reasoning, examining such topics as truth, relevance, and adequacy; deductive logic ; and induction. Sixteen fallacies in thinking are also described through extensive illustrations and applications. The final section of the book offers a unique study of what constitutes proof in several different areas--including politics, advertising, law, and social issues--as well as in the academic disciplines of literature, science, history, and ethics. The author describes the various rules of evidence, using essays by major figures in each field as examples. An ideal text for courses in critical thinking, informal logic, and reasoning and writing, The Voice of Reason offers numerous pedagogical features including a host of examples; assignments, exercises, and puzzles at both the halfway point and at the end of each chapter; cartoons and quotations throughout; and practical applications of theoretical concepts. An extensive Instructor's Manual contains answers to the exercises that appear throughout the text. (shrink)

A philosophical analysis is offered of the relationship between knowledge and liberation in Buddhism. Buddhists often consider the knowledge of impermanence as a key to liberation from craving, attachment, and hence suffering. However, it can be objected that one may know that things are impermanent and yet still be subject to craving and attachment. In the face of this objection, critical consideration is given to five ways in which one might preserve the claim that a knowledge of things as they (...) actually are results in liberation from craving and attachment. Many Buddhists might in fact reject the thesis that knowledge alone, no matter how it is characterized, is a sufficient condition for liberation. (shrink)

The text consists of essays that revolve around the question of the nature and meaning of philosophy, even as it demonstrates philosophy's significance and relevance to some fundamental human problems and issues. The essays present diverse views of what philosophy might be and might aspire to be, with contributors being influenced by a wide range of philosophical approaches and traditions. The conversations also cut across disciplinary boundaries to interrogate and utilize ideas taken from ethics, epistemology, metaphysics, literary studies, cultural studies, (...) and the sociology of science. Traversing regional boundaries, the essays show philosophical analysis at work in exploring some issues pertinent to African, Caribbean, European, and American experiences, even while not ignoring Asian traditions. The collection presents interesting and intriguing views on how philosophical inquiry can illuminate various pressing problems: development, conflict, the discriminating preservation of worthwhile traditions, and the prevalence of apathy. It also reflects the vitality and multifaceted nature of philosophical discourse in grappling with live issues. The edited text is a comprehensive, balanced, and unique anthology of readings capturing the diversity of philosophical investigation. (shrink)

The Southern Transjordan Edomite Plateau and the Dead Sea Rift Valley: The Bronze Age to the Islamic Period. By Burton MacDonald. Oxford: Oxbow Books, 2015. Pp. ix + 118, 49 pls. $120.

Emptiness Appraised. A Critical Study of Nagarjuna's Philosophy. David F. Burton. Curzon Press, Richmond 1999. XV, 233 pp. £40.00. ISBN 0 7007 1066 3.

Compiled by disciples of Confucius in the centuries following his death in 479 B.C.E., _The Analects of Confucius_ is a collection of aphorisms and historical anecdotes embodying the basic values of the Confucian tradition: learning, morality, ritual decorum, and filial piety. Reflecting the model eras of Chinese antiquity, the Analects offers valuable insights into successful governance and the ideal organization of society. Filled with humor and sarcasm, it reads like a casual conversation between teacher and student, emphasizing the role of (...) the individual in the attainment of knowledge and the value of using historical events and people to illuminate moral and political concepts. Confucius's teachings focus on cultural and peaceful pursuits and the characteristics of benevolent and culturally distinguished government. He also discusses ancestor worship and other rites performed for the spirits of the dead. The single most influential philosophical work in all of Chinese history, _The Analects of Confucius_ has shaped the thought and customs of China and neighboring countries for centuries. Burton Watson's concise translation uses the pinyin romanization system and keeps explanatory notes to a minimum, yet his intimate knowledge of the Confucian tradition and precise attention to linguistic detail capture the original text's elegance, cogency, and wit. (shrink)

Xunzi asserted that the original nature of man is evil, differing on this point from Mencius, his famous predecessor in the Confucian school. In the most complete, well-ordered philosophical system of his day, Xunzi advocated the counteraction of man's evil through self-improvement, the pursuit of learning, the avoidance of obsession, and observance of ritual in life. Readers familiar with Xunzi's work will find that Burton Watson's lucid translation breathes new life into this classic. Those new to Xunzi will find (...) his ideas on government, language, and order and safety in society surprisingly close to concerns of our own age. (shrink)

Only by inhabiting Dao (the Way of Nature) and dwelling in its unity can humankind achieve true happiness and freedom, in both life and death. This is Daoist philosophy's central tenet, espoused by the person--or group of people--known as Zhuangzi (369?-286? BCE) in a text by the same name. To be free, individuals must discard rigid distinctions between right and wrong, and follow a course of action not motivated by gain or striving. When one ceases to judge events as good (...) or bad, man-made suffering disappears, and natural suffering is embraced as part of life. Zhuangzi elucidates this mystical philosophy through humor, parable, and anecdote, using non sequitur and even nonsense to illuminate truths beyond the boundaries of ordinary logic. Boldly imaginative and inventively written, the _Zhuangzi_ floats free of its historical period and society, addressing the spiritual nourishment of all people across time. One of the most justly celebrated texts of the Chinese tradition, the _Zhuangzi_ is read by thousands of English-language scholars each year, yet, until now, only in the Wade-Giles romanization. Burton Watson's conversion to pinyin in this book brings the text in line with how Chinese scholars, and an increasing number of other scholars, read it. (shrink)

Compiled by disciples of Confucius in the centuries following his death in 479 B.C.E., _The Analects of Confucius_ is a collection of aphorisms and historical anecdotes embodying the basic values of the Confucian tradition: learning, morality, ritual decorum, and filial piety. Reflecting the model eras of Chinese antiquity, the Analects offers valuable insights into successful governance and the ideal organization of society. Filled with humor and sarcasm, it reads like a casual conversation between teacher and student, emphasizing the role of (...) the individual in the attainment of knowledge and the value of using historical events and people to illuminate moral and political concepts. Confucius's teachings focus on cultural and peaceful pursuits and the characteristics of benevolent and culturally distinguished government. He also discusses ancestor worship and other rites performed for the spirits of the dead. The single most influential philosophical work in all of Chinese history, _The Analects of Confucius_ has shaped the thought and customs of China and neighboring countries for centuries. Burton Watson's concise translation uses the pinyin romanization system and keeps explanatory notes to a minimum, yet his intimate knowledge of the Confucian tradition and precise attention to linguistic detail capture the original text's elegance, cogency, and wit. (shrink)

This is one of the most justly celebrated texts of the Chinese tradition - impressive for both its bold philosophical imagination and its striking literary style. Accepting the challenge of translating this captivating classic in its entirety, Burton Watson has expertly rendered into English both the profound thought and the literary brilliance of the text.

This is Daoist philosophy’s central tenet, espoused by the person—or group of people—known as Zhuangzi (369?-286? B.C.E.) in a text by the same name.

This paper argues that Quaker business ethics can be understood as a MacIntyrean tradition. To do so, it draws on three key MacIntyrean concepts: community, compartmentalisation, and the critique of management. The emphasis in Quaker business ethics on finding unity, as well as the emphasis that Quaker businesses have placed on serving their local areas, accords with MacIntyre’s claim that small-scale community is essential to human flourishing. The emphasis on integrity in Quaker business ethics means practitioners are well-placed to resist (...) the compartmentalising pressures of contemporary work. Quaker business ethics is also highly critical of the manipulative forms of management that MacIntyre regards as dominant. As such, Quaker business ethics provides evidence that more morally ameliorative forms of running business organisations is possible, even if they remain difficult to achieve. (shrink)

Thinking about God is historical thinking and that in two senses : the idea of God has a history, and those who think about God think through an historically formed mind. The task of the theologian, is not the attempt to move outside his historicity - such an attempt constitutes a fallacy and not a virtue - but to accept its implications and limitations. Methodologically this means that the theologian must point to the historical perspectives that underlie the idea of (...) God in its development and, in his own constructive thought, must work self-consciously with an historical perspective informed by the psychological and cosmological understanding of his own time. This book centers on that idea which traditionally has been associated with the very godness of God - the idea of divine abso luteness - and puts certain historical, logical, religious and, finally, cosmological questions to it. The roots of that idea lie in Greek thought, which entered Christian theology via the early church fathers; even so, there is much indication, particularly in Patristic trinitarian thought, that the Biblical heritage is pushing theological thinking towards a social or relative concept of divine being (ch. 1). (shrink)